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Importantly, the cytokine transduces a pro-inflammatory signal from the periphery to the CNS through endothelial cells of the bloodbrain barrier [75, 76]

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This decrease in enzyme activity can lead to a buildup of a substance called homocysteine in the blood, which is associated with an increased risk of cardiovascular disease, stroke, and other health problems

Subjects in the GLP-1 RA group had more complications of diabetes (26.0% vs