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Specifically, the analysis reported hazard ratios around 1.151.22 for colorectal or colon cancer with the highest versus lowest intake levels, and similar elevations for rectal cancer, indicating about a 1520% higher relative risk in heavy consumers

Glucagon Inhibition: GLP-1 suppresses glucagon, another hormone produced by the pancreas that signals the liver to release stored glucose into the bloodstream

But the signal is consistent across studies and across populations, and it is exactly the kind of signal that pharma uses to justify a registration trial

The fat loss is still happening

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Research suggests semaglutide can lower the risk of heart disease in people with obesity or diabetes