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require documentation of indication, dosing, and clinical response Biologics (IL-12/23 inhibitor): Ustekinumab (Stelara, J3357) FDA-approved for moderate-to-severe CD

In the Phase 3 REDEFINE 1 trial, the most commonly reported adverse events included nausea, vomiting, diarrhoea, and constipation

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0.25mg dose: Draw to 7.5 units (round to 7 or 8) 0.5mg dose: Draw to 15 units 1.0mg dose: Draw to 30 units 1.7mg dose: Draw to 51 units 2.0mg dose: Draw to 60 units 2.4mg dose: Draw to 72 units These unit measurements are easier to read on a standard insulin syringe, which is why the 3mL reconstitution has become the default recommendation across most research communities

Appetite gradually returns during this period

Starts at 1 mg and builds slowly through 4 mg before increasing