The high response rate to treatment with IBAT (odevixibat) in these patients suggests that in PFIC4, despite tight junction dysfunction, there is a regular passage of BAs from the hepatocytes to the biliary tree and the bowel, allowing odevixibat to interrupt the enterohepatic circulation and decrease the recirculating BA pool [1, 42, 47]
The diversity of actions of both components of this axis in promoting the growth of skeletal muscle increases the bases to explain their synergistic effect in the development of cardiac diseases characterized by hyperplasic and hypertrophic muscle fibers
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Changes in plasma GLP-1 after oral administration of the protein under the oral glucose tolerance test
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control, 194) showed no significant effect of NAC supplementation on SHGB levels (WMD: 168 nmol/l, 95 % CI (210, 545), P = 0383) (online Supplementary Fig