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The up-regulation of integrin proteins is mediated by ADP, thromboxane A2 though a G protein mediated signaling pathway which includes Rho GDP-dissociation inhibitor 2, which also seen as up-regulated in this study

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Moreover, emerging evidence suggests that immuneECM interactions, the adiposeliverthyroid axis, and gut microbiota may represent key modulators of this pathological interplay and merit deeper investigation (191, 192)

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Results may vary depending on individual metabolism, baseline nutrient levels, and overall health