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LPS/ATP-stimulated macrophages exhibited significant up-regulation of pro-inflammatory cytokines IL-18 and IL-1, while GYY4137 treatment drastically mitigated LPS-ATP elicited inflammatory responses (Fig

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Indeed, to achieve an intake of 10 g of L-citrulline, ingestion of around 35 kg of fresh watermelon (highest concentration of all foods) would be required and this is not only impractical for athletes (Davis et al