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In severe cases, patients may develop visual disturbances due to optic neuropathy

This is because: Older adults make less stomach acid, which is needed for B12 absorption

Presentation after next 2 weeks ( c, b ): in control rats, drinking water was continuously given (12 ml/day/rat) (defecation through fistula, c ) and in BPC 157 rats, BPC 157 (10 g/kg/day) was given in drinking water (0.16 g/ml/day/rat) (fistula closed, b )

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Onset varies just as much as route: Semax and Selank tend to show effects within hours, whereas the structural compounds, Dihexa and P21, need weeks of repeated dosing before measurable changes in brain connections appear