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Here's how the two groups compared on reaching key weight loss milestones: Waist circumference also shrank more with tirzepatide: an average of 18.4 cm (about 7 inches) compared to 13.0 cm (about 5 inches) with semaglutide.[1] "The SURMOUNT-5 head-to-head results demonstrated tirzepatide led to greater weight reduction compared to semaglutide," said Dr