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In 2008, Rimonabant (also known as SR141716) was withdrawn from the market worldwide after being approved in 2006 due to serious psychiatric side effects that outweighed its benefits, including suicide

Ethics declarations Conflict of interest Eden Miller received consulting fees from Abbott, Astra Zeneca, Novo Nordisk, Boehringer Ingelheim, Eli Lilly, Merck, Sanofi US, and acted as a speaker for Abbott, Boehringer Ingelheim, Eli Lilly, and Novo Nordisk

However, the specified relative risk of various biliary disorders among users of different GLP-1RAs is still unclear

Br J Dermatol 1979

Although infrequent, acute pancreatitis has been reported with GLP-1 medicines