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Dosing is individualised based on body weight, target outcome and the specific tissue or system being addressed

Tumor incidence decreased in treated animals

After 8 weeks, you see minimal improvement and conclude the peptide does not work

On one hand, blocking - arrestin2 association with MOR (but not GRK3 or S375A mutants) inhibits morphine tolerance

It signals your pancreas to produce insulin, slows gastric emptying , and activates brain circuits responsible for feeling full

Thus, it is possible that the low concentrations used here were insufficient for ER binding but sufficient to interact with ER and/or suppress esr2 transcription