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Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice

The PPI network of the target genes was created using STRING ( and the pathways were assessed via Reactome analysis for enrichment

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3 Crucially, the same study pointed to a neural, vagally mediated mechanism: the effect had the signature of vagal inhibition rather than a direct action on gastric smooth muscle

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