A separate systematic review that specifically included Retatrutide reached the same conclusion and added a twist that is directly relevant here
long-acting GLP-1RAs on AMD, long-acting agents are known to be more effective in terms of glycemic control and body weight, and it has been suggested that weight-loss mediated pathways may drive the ocular benefits associated with GLP-1RA use. However, they pointed out that this study cohort was matched for hemoglobin A1c and BMI, which decreases the likelihood that the more pronounced benefit associated with long-term agents is due to these factors alone. Moreover, in obese and non-obese individuals, GLP-1 agonist therapy exhibited comparable reduced risks of dry (21% vs
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10.1038/s41598-021-88612-x 37 KazankovK.JrgensenS
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Morning vs Night: The Bioavailability Differential Oral peptides face harsh degradation in the GI tract from proteolytic enzymes and acidic pH