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Alterations in one-carbon and thiol metabolism, including increased cystathionine and choline alongside decreased 5-methyl-THF and 2-hydroxybutyrate, are consistent with pathway-level shifts centered on glutathione turnover, suggesting variation in redox capacity prior to intervention

Additionally, all external validation experiments successfully passed our sensitivity analysis, as shown in Table S7 and Supplementary Materials 1, 2, and 3

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This expansion will coincide with anticipated price drops, making these drugs accessible to even more people

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