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Two areas of emerging research deserve particular attention: Non-HIV metabolic populations: Several investigators have studied tesamorelin in adults with abdominal obesity and metabolic syndrome, with consistent signals toward VAT reduction and improvements in liver fat in patients with non-alcoholic fatty liver disease

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The latter can result in overactivation of the DNA repair enzyme poly ADP polymerase (PARP), which leads to a loss of cell viability and necrotic cell death