The SURPASS clinical trial program (Rosenstock et al., Lancet 2021) enrolled patients with baseline A1C ranging from 7.0% to 10.5%, and the medication reduced A1C by 1.87% to 2.07% depending on dose
Tirzepatide also showed improvements in lipids and cardiovascular risk factors compared to dulaglutide 1.5 mg and placebo
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How tirzepatide works: the dual-agonist advantage for effective weight loss Most GLP-1 medications work through a single hormonal pathway, stimulating glucagon-like peptide-1 receptors to slow gastric emptying, suppress appetite, and improve insulin sensitivity
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