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The opportunities in these indications can be assessed by deploying effective new product planning / opportunity assessment methodologies, including evaluating the following for each potential indication: Level of in-class / competitive activity Likelihood of technical and regulatory success (i.e., based on scientific rationale and regulatory precedent) Level and nature of unmet needs for new therapies in the disease area of interest Potential for GLP1-s to address these unmet needs Commercial attractiveness of market Potential speed to market Alignment with individual manufacturer portfolio / strategy / capabilities Conclusion Incretin mimetics have had an immense and growing impact on patient outcomes

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Inflammatory bowel disease types differ in markers of inflammation, gut barrier and in specific anti-bacterial response

Eight-week-old Bmal1 lox/lox / Pax8-rtTA /LC-1 mice and their Bmal1 lox/lox littermate mice were treated for 2 weeks with DOX at 2 mg/mL in drinking water along with 20mg/mL sucrose to induce the Cre recombinase inactivation of the Bmal1 ( Arntl ) gene

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