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Owing to the lack of high-quality cell-type-specific protein concentration data for young and old rodents, we relied on data on RNA levels to derive the concentrations of enzymes and transporters, with scaling in the aging group based on the assumption that changes in RNA directly affect enzyme concentrations (61)

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[DOI] [Google Scholar] 115.Mamede A.C., Tavares S.D., Abrantes A.M., Trindade J., Maia J.M., Botelho M.F

Although microdosing may minimize side effects, it doesnt fully remove the possibility