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In this work, a cell co-culture system was established to confirm our hypothesis that C3G extracted from red bayberry ( Myrica rubra ) can activate PPAR/ expression, enhancing GLP-1 secretion in intestinal L cell STC-1 and consequently increasing insulin release from islet cell NIT-1

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Experimental and translational studies suggest that GLP-1 receptor agonists may attenuate inflammatory signaling and microglial activation, mechanisms that could contribute to protection of retinal and optic nerve tissues in high-risk populations

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