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In particular, UA may exert different effects depending on the chemical microenvironment and concentration, including antioxidant activity and pro-oxidant action [181]

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Abstract Introduction: Methotrexate (MTX), a folic acid antagonist and nucleotide synthesis inhibitor, is a cornerstone drug used against acute lymphoblastic leukemia (ALL), but its mechanism of action and resistance continues to be unraveled even after decades of clinical use

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