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It is suggested that the ability to transfer electrons outside the cell, and thus maintain redox balance during rapid growth, results in a vast fitness advantage, and seemingly more resilient microbial population

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When targeted therapies are used in combination with MCT1/2 inhibitor AZD3965 or LDHA inhibitor NHI-Glc-2, the sensitivity is restired in SLCLC and gastric cancer and they achieve more favorable efficacy