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Estrogen-driven collagen decline accelerates during perimenopause, and substrate is typically already more depleted at baseline

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[16] [17] Sin embargo, es fundamental comprender que estos hallazgos en roedores no se han confirmado definitivamente en humanos

GLP-1 is also cleared relatively quickly by renal filtration [16]

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Along with the remodeling of intracellular signaling pathways, reactive astrocytes secrete a variety of neurotoxic and immunomodulatory molecules that profoundly influence intercellular communication and immune responses within the brain