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Particularly for tirzepatide, in the mixed effects model on a subset of the data with therapy duration greater than 180 days, there is a positive coefficient with therapy duration and weight regain after cessation with a significant P value

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Wu, Y., Tang, L., & Chen, B

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Model establishment followed the reported protocol ( 2.3 Open field test (OFT) The OFT was conducted to assess anxiety-like behavior, exploratory activity, and locomotor function in mice