The underlying mechanism might be the p21-induced increase in GSH synthesis[47]
doi: 10.18632/aging.101507 107 AuHKLinSHHuangSYYehTSTzengCRHsiehRH
Understanding these mechanisms is critical before evaluating specific protocols
obtained when the zero standard was assayed 20 times, and calculating the corresponding concentration
Furthermore, AS-IVs cardioprotective effects in heart failure appear to be dose-dependent, as demonstrated by increased expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE)-dependent genes, such as heme oxygenase-1 (HO-1), NAD(P)H: quinone oxidoreductase 1 (NQO-1), and sulfiredoxin-1 (Srxn-1), with rising AS-IV concentrations in the oxygen-glucose deprivation model (Gu et al., 2015)
Glutathione is a tripeptide protein comprised of cysteine, glutamic acid, and glycine residues