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In human dermal fibroblasts, TGF-/Smad signaling pathway is key to maintain the integrity of the dermal structure, by increasing the extracellular matrix (ECM) production, and decreasing its degradation [79]

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The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)

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