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Some patients may notice changes in appetite, cravings, or weight over time, while others may not

Louis Aronne, director of the Comprehensive Weight Control Center at Weill Cornell Medicine

If the pounds were coming off, but things have slowed down or stopped, it might be time to move up to the next dose

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As a once-weekly subcutaneous injection, tirzepatide works by enhancing insulin secretion in response to meals, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

Do side effects get worse as the dose increases