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Conflict of interest The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

There is also more evidence and reports about its possible serious adverse effects, she added

These observations have prompted growing interest in non-hormonal contributors to hypothyroidism, particularly the role of the gut microbiota

notably, metformin is an FDA-approved medication, while berberine is a natural supplement

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Receptor-binding studies have confirmed that AOD-9604 does not bind to growth hormone receptors at concentrations far exceeding therapeutic doses