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Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue

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On April 10, 2025, the Centers for Medicare & Medicaid Services (CMS) issued a sweeping update that could significantly impact how states and providers leverage federal Medicaid dollars

Our team has followed the preclinical data for years, and the consistency of its effects across different tissue types is remarkable