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The study is registered with ClinicalTrials.gov, NCT03693430

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Among all adults, 7% say they have taken or are taking these drugs to treat a chronic condition such as diabetes or heart disease either alone (5%) or in combination with intent of losing weight (3%) while 5% of adults report ever taking these drugs to lose weight but not to treat a chronic condition

Priority Three: Micronutrient Deficiencies Reduced food intake can increase the risk of vitamin and mineral deficiencies

Eight-month-old APP/PS1 mice were administered seven injections of 1 mg/kg siRNA in the form of ITP-LNP/siBACE1, IEP-LNP/siBACE1, LNP/siBACE1, ITP-LNP/siScr, LNP/siScr, or PBS (Fig