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Studies demonstrate that adults with growth hormone deficiency have significantly elevated visceral fat compared to age-matched controls with normal GH levels

GTPase signaling Guanosine triphosphatases (GTPases) are a group of enzymes that hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate

Moreover, the increased morbidity and mortality in patients with NASH is known to be closely related to the severity of liver brosis

Compared with the distribution of KGA in the cytoplasm, GAC is located in mitochondria with a lower Km-app, maintaining mitochondrial GLS metabolism in tumor cells (Gao et al., 2009