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Current as of May 31, 2023

3.4.4 Alkaloids: comprehensive miRNA biogenesis modulation Berberine targets multiple oncogenic miRNAs, including miR-21 (5070% reduction in HCT116 cells), miR-23a (2.5-fold increase in hepatoma cells), and suppression of the miR-1792 cluster in multiple myeloma

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A reducing milieu renders cofilin insensitive to phosphatidylinositol 4,5-bisphosphate (PIP2) inhibition