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GLP-1 receptor analogs can also promote neuronal growth by enhancing CREB phosphorylation and increasing levels of p-ERK/ERK

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2017;57:66676 Taylor and Francis Inc

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In 56-week studies, patients taking Contrave alongside diet and exercise lost an average of 5-9% of their body weight, compared to 1-5% with a placebo, meaning the medication contributed roughly 4-5 percentage points of additional weight loss.4,5 About 46% of patients on Contrave achieved at least 5% weight loss by week 16

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