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The drugs dont introduce something new to the bodythey connect with receptors that are already there

Tryptophan Degradation in Irritable Bowel Syndrome: Evidence of Indoleamine 2,3-Dioxygenase Activation in a Male Cohort

S-Cys-G-S-Cys-Cys-K...-COOH) [22]

Dysregulation of ERAD components has also been implicated in disease pathogenesis

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These findings support a functional preference for the L-lactyl donor in enzymatic reactions, although explicit stereoselectivity against D-lactyl-CoA remains to be fully established [52]