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Glucagon opposes insulin action, which creates a more complex interaction profile with diabetic medications

Glickman and Shapiro say these are the main culprits

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doi: 10.1016/0167-4889(83)90057-5

An ADA 2025 late-breaker abstract reported that ecnoglutide also produced larger HbA 1c drops than dulaglutide at parallel doses [Diabetes Journals], reinforcing its metabolic edge

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