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10.3945/ajcn.113.058313 42 GuoL.YangJ.YuanW.LiC.LiH.YangY.et al (2024)

Growing interest in GLP-1-inspired wellness solutions despite limited clinical evidence

Early studies have reported substantial reductions in body weight, contributing to increasing interest in this emerging therapy

and Sadiya S

While GLP-1 medications dont directly deplete nutrients, people eating less may develop low or borderline levels, particularly: Vitamin B12 (especially if also taking metformin) Vitamin D Iron (especially in menstruating women) These labs arent required for everyone

In a phase 2 trial of 338 adults with obesity, retatrutide given once weekly caused dose-dependent weight loss over 48 weeks