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Translational gaps in therapeutic development: Current NRF2-targeting strategies struggle to balance efficacy and specificity, with small-molecule inhibitors/activators showing poor selectivity and epigenetic-based approaches facing delivery challenges in vivo

2011, 3, 1265-1281 Nature Biotechnology

The optimal UA reduction was achieved with the mass ratio of PDA to Pt at 1:1, which is comparable to the efficacy observed at 1:0.5 (Figure S10b)

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It is a foundational requirement that amplifies every other intervention

Value of GLP-1 receptor agonists versus long-acting insulins for type 2 diabetes patients with and without established cardiovascular or chronic kidney diseases: a model-based cost-effectiveness analysis using real-world data