It binds directly to heavy metals like mercury, lead, and cadmium, as well as pesticide residues and alcohol byproducts, converting them into water-soluble compounds the body can excrete through urine or bile
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Knockdown of METTL14 by siRNA significantly reduces GPX4 mRNA m^6A modification, restores GPX4 expression, alleviates ECM degradation, and ultimately inhibits chondrocyte ferroptosis in vitro (176)
It is produced naturally in the body and is present in every cell
The most common types of free radicals in biological systems are reactive oxygen species (ROS) and reactive nitrogen species (RNS)
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