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Indeed, the transcription of HIF-regulated genes controls different steps of tumor invasion and metastasis, including EMT, activation of MET signaling, recruitment of stromal cells, vascular mimicry and vessel co-option [299]

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At that concentration, a 300 mcg dose is about 0.18 mL (18 units on a U-100 syringe) and a 500 mcg dose is about 0.30 mL (30 units)