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After being taken up by the liver from the bloodstream, melatonin undergoes enzymatic conversion to produce 6-hydroxymelatonin sulfate, which is then excreted in the urine [28]

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Solution turns cloudy after initial clarity A solution that was clear after reconstitution but turns cloudy during storage typically indicates protein aggregation due to temperature excursion (the vial got too warm or too cold) or bacterial contamination