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But theyre also very expensive, and insurers are trying to control spiraling costs

Patients enrolled in the PIONEER 2 [15], PIONEER 3 [16], SUSTAIN 2 [17], and SUSTAIN 8 [18] trials had type 2 diabetes that was uncontrolled by metformin (with or without sulfonylurea) and were treated with an additional oral/subcutaneous GLP-1RA (semaglutide), oral SGLT-2i (empagliflozin/canagliflozin), or oral DDP-4i (sitagliptin)

For researchers whose metabolic profiles include kidney function concerns alongside weight management goals, dulaglutide fills a specific clinical niche that tirzepatide does not yet have formal data to support

The side effects of not drinking enough water may be worse as you go through your weight loss journey

I could barely drink my bedtime alcohol anymore

Early trials suggest these might produce even greater weight loss, potentially approaching 30% or more