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Weight loss expectations: In landmark trials such as STEP 1 (Semaglutide Treatment Effect in People with obesity) and SCALE (Satiety and Clinical Adiposity Liraglutide Evidence), participants achieved average weight reductions of 14.9% of initial body weight over 68 weeks with semaglutide 2.4 mg weekly, and approximately 8% with liraglutide 3.0 mg daily

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Reducing alcohol, even temporarily, significantly decreases metabolic burden

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Specifically, subgroups were examined by disease, mean age, gender ratio, and RCT outcomes categorized both according to general AE/SAE and high risk of bias or not

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