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This is not a safety concern specific to tirzepatide

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PIONEER 4: Head-to-head vs liraglutide 1.8 mg 1,2 Study design: 52-week, randomized, double-blind, double-dummy, active controlled, and placebo-controlled phase 3a trial designed to assess the safety and efficacy of semaglutide tablets vs subcutaneously injected GLP-1 RA, liraglutide

Timing: For optimal results, consume preferably 30 minutes before exercise

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And dietitians are positioned to close it