Women who are or may become pregnant should avoid the compound entirely
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In a randomized controlled trial, 120 women with episodic migraines were randomly assigned to receive either 300 mg B1, 80 mg B6, 2 mg folic acid, 500 mcg B12, a combination of all of these B vitamins at the aforementioned dosages, or placebo daily for 12 weeks
Benefits from vitamin B12 can vary
Metformin users, common among type 2 diabetes patients who then add semaglutide, face a double hit since metformin independently reduces B12 absorption by 10-30% over long-term use
doi:10.1002/14651858.cd004326