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This article reviews the genetic mechanism and progress in the diagnosis and treatment of GDH-HI, with a view to improving clinicians' understanding of GDH-HI

It also acts in parts of the brain involved in mood and reward

HS also shares pathogenic pathways with immune-mediated diseases such as inflammatory bowel disease (IBD), particularly Crohns disease, and spondyloarthritis [34], reflecting common IL-23/Th17-driven mechanism [35] (Fig

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(2,3,4) In the liver, glutathione is a key player in Phase II (hyperlink to first detox article), combining with medications and toxic substances to neutralize them, preparing them for excretion