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A 2022 study published in JAMA Network Open found that people taking antidepressants experienced somewhat reduced weight loss with GLP-1 medications compared to those not taking antidepressants

Arthritis: Doubles the risk of arthritis, especially in weight-bearing joints like the knees and hips

when the feedback regulation mechanism between pancreatic islets-adipocytes is damaged, the sensitivity of insulin to LP decreases

Fiber is critical too, as most Americans dont consume enough of the nutrient to begin with, Despain noted

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Weight loss was more pronounced with a higher dose of the drug, although the impact on glucose levels was less dose dependent