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CHAC1 is primarily regulated by the UPR pathway, specifically the PERK/eIF2/ATF4/ATF3/CHOP cascade, which is activated under conditions of ER stress

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J Biol Chem 244(13):37073713 Meister A (1973) On the enzymology of amino acid transport

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We found that the endocytosis and dynamin inhibitor dyngo-4A (30 M) (33) abrogated the internalization of FAM(2836), implicating endocytosis as a method of cellular uptake of GLP-1(2836) (Supplemental Figure 6, A and B)