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Key variants including GLP1R rs6923761, GIPR rs1800437, and FTO rs9939609 relate to metabolic phenotypes and appetite regulation pathways that influence both liver fat accumulation and treatment outcomes

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Activated Nrf2 mediates induced expression of an array of enzymes and signaling proteins to regulate drug metabolism, antioxidant defense, and oxidant signaling, thereby influencing oxidant physiology and pathology