2018 Nov 14;10(467):eaar7047
High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance
Ethics declarations Ethics approval and consent to participate As this study is a systematic review and meta-analysis of previously published data, ethical approval was not required by the authors institutional review board
O composto atua diretamente no metabolismo celular, auxiliando o transporte de cidos graxos de cadeia longa at a mitocndria, onde so convertidos em energia utilizvel pelo msculo e demais tecidos musculares
It treats these as signals that discontinuation may not be appropriate yet, or that the approach needs to change
D.PhillipsT