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Paracetamol Paracetamol-induced hepatotoxicity represents the result of an imbalance between metabolic detoxication of paracetamol, via conjugation with glucuronic acid and sulphate, and metabolic activation to an unstable toxic metabolite ( N -acetyl- p -benzoquinone imine, NAPQI) via oxidation by cytochrome P450
The bottom line Our liver needs adequate levels of glutathione to function optimally and flush out harmful toxins, crucial for overall health and well-being
Side effects that are possible with Glutathione include hypersensitivity reaction, allergic reaction, palpitations, chills, fever, insomnia and rash
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If a patient is fortunate enough to seek out and obtain early medical attention (typically within 4 hours of the acute APAP ingestion), activated charcoal can be effective in limiting drug absorption, unless there are obvious contraindications, such as an unprotected airway or compromise of the gastrointestinal tract