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The laddering in lysates corresponds to the predicted molecular weights of monomeric hCC and discrete multimers of hCC (dimer, trimer, and tetramer), which we refer to as smaller species (dimer, trimer, and tetramer) and low-molecular-weight (LMW) complexes

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This type of evaluation becomes especially important in cases for which the APAP-associated liver failure was a consequence of intentional ingestion, as a repeat episode of over-ingestion will inevitably cause harm to the transplanted organ and squandering of a limited resource

For anyone weighing the benefits against these risks, comparing glutathione IV to oral supplementation can provide additional perspective