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Studies indicate that any reduction in metabolic rate during GLP-1 treatment is primarily attributable to: Decreased body mass : A smaller body naturally requires less energy for basic physiological functions Loss of metabolically active tissue : Both fat and lean tissue contribute to resting energy expenditure Normal adaptive thermogenesis : The body's natural response to caloric restriction and weight loss Comparative studies examining GLP-1-induced weight loss versus equivalent weight loss through diet and exercise show similar metabolic adaptations, suggesting the medications do not cause additional metabolic suppression beyond what would be expected with weight loss by any means
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A second group received intermittent intramuscular injections on days 7, 9, 14, and 16
Their results show that the availability of extracellular GSH can alter sensitivity to different treatments, or even confer resistance to drugs that block the uptake of these amino acids, with the implications that entails
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